Glucose-Responsive Insulin Through Bioconjugation Approaches
نویسندگان
چکیده
منابع مشابه
Glucose-responsive insulin delivery systems.
La diabetes es un trastorno de muy alta prevalencia, caracterizado por un déficit de acción insulínica, que da lugar a concentraciones elevadas de glucosa en sangre. Las terapias sustitutivas son muy imperfectas: en pocos casos consiguen controlar de manera estable los valores de glucemia, se adaptan mal a las perturbaciones (ingestas, ejercicio, etc.), provocan hipoglucemias e implican un esfu...
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A new glucose-responsive polymeric composite membrane that provided pulsatile insulin release was developed in our laboratory previously. To develop a clinically useful insulin delivery system, this study was designed to investigate factors influencing insulin stability during delivery by this membrane. The effects of stirring, release duration, insulin concentration and surfactant on insulin s...
متن کاملThyroid Hormone Promotes Postnatal Rat Pancreatic β-Cell Development and Glucose-Responsive Insulin Secretion Through MAFA
Neonatal β cells do not secrete glucose-responsive insulin and are considered immature. We previously showed the transcription factor MAFA is key for the functional maturation of β cells, but the physiological regulators of this process are unknown. Here we show that postnatal rat β cells express thyroid hormone (TH) receptor isoforms and deiodinases in an age-dependent pattern as glucose respo...
متن کاملThyroid Hormone Promotes Postnatal Rat Pancreatic b-Cell Development and Glucose-Responsive Insulin Secretion Through MAFA
Neonatal b cells do not secrete glucose-responsive insulin and are considered immature. We previously showed the transcription factor MAFA is key for the functional maturation of b cells, but the physiological regulators of this process are unknown. Here we show that postnatal rat b cells express thyroid hormone (TH) receptor isoforms and deiodinases in an age-dependent pattern as glucose respo...
متن کاملA glucose-responsive insulin therapy protects animals against hypoglycemia.
Hypoglycemia is commonly associated with insulin therapy, limiting both its safety and efficacy. The concept of modifying insulin to render its glucose-responsive release from an injection depot (of an insulin complexed exogenously with a recombinant lectin) was proposed approximately 4 decades ago but has been challenging to achieve. Data presented here demonstrate that mannosylated insulin an...
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ژورنال
عنوان ژورنال: Journal of Diabetes Science and Technology
سال: 2019
ISSN: 1932-2968,1932-2968
DOI: 10.1177/1932296819854105